内脂素/前B细胞克隆增强因子与妊娠

摘要

内脂素/前B细胞克隆增强因子(visfatin/PBEF)作为新发现的脂肪因子,主要在内脏脂肪和大网膜中表达.具有类胰岛素作用、参与炎症反应和免疫调节等功能.妊娠期妇女处于特殊的生理状态,能量代谢发生特征性改变.最新观点认为妊娠合并症,如妊娠期糖尿病和妊娠期高血压疾病均存在胰岛素抵抗,是妊娠妇女体内代谢功能紊乱所致.近年对visfatin/PBEF的结构和功能、其与代谢综合征、子痫前期,妊娠期糖尿病和胎儿生长受限关系的研究提示,visfatin/PBEEF可能参与妊娠相关疾病的发生和发展.就近年关于visfatin/JPBEF和妊娠合并症的相天研究综述.%Visfatin/pre-B-cell colony-enhancing factor(PBEF) has recently been identified as a novel adipokine with insulin-mimetic effects and a regulatory factor in pro-inflammatory and immunomodulating processes.Visfatin is mainly expressed in adipose tissue, with particularly high level in both visceral and omental adipose tissue.Some clinical associated studies confirmed the association of visfatin and GDM, pre-eclampsia, metabolic syndrome,intrauterine growth restriction. Similarly, the relationship of visfatin with parameters of glucose metabolism and insulin resistance were contradictory, and overall there was no clear effect of visfatin on metabolism, normal and complicated pregnancies. Over the last few years, it has become obvious that obesity and various components of the metabolic syndrome are strongly linked with the adipokine such as visfatin/PBEF. The review aims to summarize reported findings concerning the role of visfatin/PBEF in normal and complicated pregnancies.