原发性开角型青光眼患者眼血流动力学的改变及与中医证型关系的研究

摘要

Objective To explore the relationship between the changes of ocular hemodynamics in patients with primary open angle glaucoma and the TCM Syndrome Types. Methods The changes of ocular hemodynamics from 102 cases of prima-ry open -angle glaucoma patients were detected by using color doppler imaging (CDI). Results Compared with the normal group, PSV, EDV, AV in flow parameters of ophthalmic artery (OA) in the patients with open angle glaucoma and TCM syndrome types (liver depression and Qi stagnation syndrome, phlegm-damp invading the eyes syndrome, liver-kidney Yin deficiency syndrome) were statistically significant (P<0.05 or P<0.01). In the blood flow parameters of central retinal artery (CRA), PSV, EDV, AV were also satistically significant (P<0.05 or P<0.01), the degrees of variation were, in order, liver con-straint and Qi stagnation group>phlegm-damp invading the eyes group>liver-kidney Yin deficiency group. Conclusion The blood flow rate of OA and CRA in patients with primary open angle glaucoma decreased significantly, blood flow resistance increased, and with ocular local blood circulation disorders. The blood flow parameters of OA and CRA can be used as an important index to reflect the degree of local blood stasis between the open angle glaucoma and TCM syndrome types.%目的：探讨原发性开角型青光眼患者眼血流动力学的改变及其与中医辨证分型之间的关系。方法采用彩色超声多普勒成像(CDI)对102例原发性开角型青光眼患者眼血流动力学的改变进行了检测。结果开角型青光眼及其中医证型（分为肝郁气滞证、痰湿犯目证、肝肾阴虚证）在眼动脉（OA）血流参数中，与正常组相比，PSV、EDV、AV差异均有统计学意义(P＜0.05或P＜0.01)；在视网膜中央动脉（CRA）血流参数中，与正常组相比，PSV、EDV 和AV差异均有统计学意义(P＜0.05或P＜0.01),其变异程度依次为肝郁气滞证组＞痰湿犯目证组＞肝肾阴虚证组。结论原发性开角型青光眼患者OA和CRA的血流速度下降明显，血流阻力增加，眼局部血液循环障碍，OA和CRA的血流参数可作为反映开角型青光眼及其中医证型间局部血瘀程度的一项重要指标。