Objective:to analyze the clinical effect of self-made Yiqi Huoxue formula in treatment of chronic heart failure(CHF) of coronary heart disease and its action on level of inflammatory factors. Methods:120 cases of CHF patients with coronary heart dis-ease were divided into observation group and control group,according to the odd or even numbers of sequence number with 60 cases in each group; the control group was treated with routine western medicine, the observation group with Yiqi Huoxue Formula treatment based on conventional therapy. Compare TCM syndromes and heart function improvements,and inflammatory factor C reactive protein (CRP) and interleukin -6 (IL-6) and N terminal pro brain natriuretic peptide (NT-proBNP) level after treatment. Results:⑴ TCM syndrome and heart function improvement rate of the observation group after the treatment were 90.00%,91.67%, the control group 78.33%,75.00%,and the difference was significant( P < 0.05);⑵the left ventricular ejection fraction(LVEF) in the 2 groups after treatment were higher than that before treatment,left ventricular diastolic at the end of the diameter(LVEDD) of the observation group decreased,and there was significant difference before and after treatment ( P < 0.05); LVEF in the observation group was higher than that of the control group, the LVEDD level was lower, and there was significant difference between the 2 groups ( P< 0.05);⑶ Serum CRP,NT-proBNP and IL-6 of the 2 groups were significantly decreased after treatment,and there was significant difference before and after treatment( P < 0.05);CRP,NT-proBNP and IL-6 levels of the observation group were significantly lower than that of the control group,there was significant difference between the 2 groups after treatment ( P < 0.05). Conclusion: The treatment of coronary heart disease with self-made Yiqi Huoxue Formula can effectively improve cardiac function,relieve clinical symp-toms,improve cardiac function and reduce the level of inflammatory factors.%目的:分析自拟益气活血方治疗冠心病慢性心力衰竭 (CHF) 临床效果及对炎症因子水平的影响.方法:选择冠心病CHF患者120例,根据入组序列号奇偶数分为观察组与对照组各60例,其中对照组给予常规西医综合治疗,观察组在常规西医治疗的基础上给予自拟益气活血方治疗,比较2组治疗后中医证候、心功能改善情况及炎症因子C反应蛋白 (CRP)、白介素-6 (IL-6)、N端脑钠肽前体 (NT-proBNP) 水平.结果:⑴观察组治疗后中医证候和心功能改善有效率为90.00%、91.67%,对照组为75.00%、78.33%,比较差异有显著性( P <0.05); ⑵2组治疗后左室射血分数 (LVEF) 均较治疗前增高,观察组治疗后左心室舒张末期内径(LVEDD) 降低,治疗前后差异有显著性 ( P <0.05),其中观察组治疗后LVEF高于对照组,LVEDD水平低于对照组,2组治疗后比较差异有显著性 ( P <0.05); ⑶2组治疗后血清CRP、NT-proBNP、IL-6水平均较治疗前明显降低,治疗前后差异有显著性 ( P <0.05),其中观察组治疗后血清CRP、NT-proBNP、IL-6水平明显低于对照组,2组治疗后比较差异有显著性 ( P <0.05).结论:自拟益气活血方治疗冠心病CHF可有效改善心功能,缓解临床症状,改善心功能,降低炎症因子水平.
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