糖尿病患者血浆氧化修饰低密度脂蛋白测定及临床意义

摘要

目的探讨氧化修饰低密度脂蛋白(oxidized modified low-density lipoprotein,ox-LDL)在糖尿病患者继发动脉粥样硬化性并发症中的作用和意义。方法采用酶联免疫吸附实验（ELISA）测定90例糖尿病患者和30例健康对照者血浆ox-LDL的水平。结果糖尿病患者具有较高水平的ox-LDL，而且2型糖尿病患者明显高于1型糖尿病患者，有血管并发症者高于无此症者，糖尿病病程也可影响ox-LDL的水平。LDL的过氧化与血糖控制水平有关。结论 ox-LDL在糖尿病患者动脉粥样硬化性并发症的发生中起着重要作用。治疗糖尿病的同时适当应用抗氧化剂，可防止和延缓其动脉粥样硬化并发症的出现。%Objective　To explore the significance of plasma oxidized modified low-density lipoprotein (ox-LDL) in diabetes mellitus(DM) with atherosclerosis.Methods　The levels of plasma ox-LDL were measured by enzyme-link immunoabsorbent assay(ELISA) in 90 patients with DM and 30 controls.Results　The plasma ox-LDL level in patients with DM was significantly higher than that in normal controls. Type two DM patients showed higher ox-LDL level than type one DM patients.Higher ox-LDL levels could be found in patients with vascular complications and the patients with longer clinical course.Plasma ox-LDL was correlated with fast blood-sugar in DM patients.Conclusion　ox-LDL plays an important role in the pathogenesis of atherosclerosis in DM patients.Proper uses of antioxidants may prevent the DM patients from occurance of atherosclerotic complication or slow down the pathological process.