Objective:To discuss the effect of intensity modulated radiation therapy combined with paclitaxel + en-dostar chemotherapy on serum malignant molecule levels in patients with locally advanced non-small cell lung cancer.Methods:Patients with locally advanced NSCLC who were treated in the hospital between February 2015 and January 2017 were collected and divided into control group(n=59)and research group(n=59)by random number table.Control group received the rou-tine paclitaxel + endostar chemotherapy after the operation,and research group underwent intensity modulated radiation thera-py combined with paclitaxel + endostar chemotherapy after the operation.The differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were compared between the two groups before and after treatment.Results:Before treatment,the differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were not statistically sig-nificant between the two groups.After treatment,serum TK1,CYFRA21-1,Pro-GRP,CEA,CA125 and SCC-Ag levels of research group were lower than those of control group;serum EGFR,COX-2,VEGF,HIF-1α and MMP-2 levels of research group were lower than those of control group.Conclusion:Postoperative intensity modulated radiation therapy combined with paclitaxel + endostar chemotherapy can effectively reduce the serum malignant molecule levels and optimize the illness in pa-tients with local advanced NSCLC.%目的:探讨调强放疗联合紫杉醇+恩度化疗对局部晚期非小细胞肺癌患者血清恶性分子含量的影响.方法:收集2015年2月-2017年1月间在本院接受治疗的局部晚期NSCLC患者作为研究对象,经随机数表法分为对照组及研究组各59例.对照组患者接受手术后常规紫杉醇+恩度化疗,研究组患者接受手术后调强放疗联合紫杉醇+恩度化疗.对比两组患者治疗前后血清中NSCLC相关肿瘤标志物、血管新生指标含量的差异.结果:治疗前,两组患者血清中NSCLC相关肿瘤标志物、血管新生指标含量的差异无统计学意义.治疗后,研究组患者血清中 TK1、CYFRA21-1、Pro-GRP、CEA、CA125、SCC-Ag的含量低于对照组患者;研究组患者血清中EGFR、COX-2、VEGF、HIF-1α、MMP-2的含量低于对照组患者.结论:局部晚期NSCLC患者术后接受调强放疗联合紫杉醇+恩度化疗,可有效降低血清恶性分子含量、优化病情.
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