阿奇霉素与甘草锌联合治疗对支原体肺炎患儿炎症反应程度及免疫应答功能的影响

摘要

目的:探讨阿奇霉素与甘草锌联合治疗方案对支原体肺炎患儿炎症反应程度及免疫应答功能的影响.方法:收集2014年1月~2017年1月间在本院接受治疗的肺炎支原体患儿150例,按照随机数表法分为对照组、观察组,各75例.对照组患儿接受阿奇霉素治疗,观察组患儿接受阿奇霉素与甘草锌联合治疗,均持续14 d,对比两组患儿治疗前后血清中炎症因子、Th17/Treg细胞因子、免疫球蛋白含量的差异.结果:治疗前,两组患儿血清中炎症因子、Th17/Treg细胞因子、免疫球蛋白含量的差异无统计学意义(P>0.05).治疗后,观察组患儿血清中炎症因子白介素(IL)-6、IL-12、IL-13、单核细胞趋化蛋白-4(MCP-4)的含量低于对照组患儿(P<0.05);血清中Th17/Treg细胞因子IL-17、IL-25的含量低于对照组患者,IL-10、IL-35的含量高于对照组患者(P<0.05);血清中免疫球蛋白免疫球蛋白(Ig)A、IgG、IgM的含量高于对照组患儿(P<0.05).结论:阿奇霉素与甘草锌联合治疗可有效降低支原体肺炎患儿的全身炎症反应,优化免疫功能.%Objective: To study the effect of azithromycin combined with licorzinc therapy on inflammatory response and immune response in children with mycoplasma pneumonia.Methods: A total of 150 children with mycoplasma pneumonia who were treated in our hospital between January 2014 and January 2017 were collected and divided into control group and observation group according to the random number table, with 75 cases in each group.Control group received azithromycin therapy while observation group received azithromycin combined with licorzinc therapy, and both therapies lasted for 14 days.The differences in serum levels of inflammatory factors, Th17/Treg cytokines and immunoglobulin were compared between the two groups before and after treatment.Results: Before treatment, differences in serum levels of inflammatory factors, Th17/Treg cytokines and immunoglobulin were not statistically significant between two groups of patients (P>0.05).After treatment, serum inflammatory factors IL-6, IL-12, IL-13 and MCP-4 levels of observation group were significantly lower than those of control group (P<0.05);serum Th17/Treg cytokines IL-17 and IL-25 levels were significantly lower than those of control group (P<0.05) while IL-10 and IL-35 levels were significantly higher than those of control group (P<0.05);serum immunoglobulin IgA, IgG and IgM levels were significantly higher than those of control group (P<0.05).Conclusions: Azithromycin combined with licorzinc therapy can effectively reduce systemic inflammatory response and optimize immune function in children with mycoplasma pneumonia.