高渗盐水+沙丁胺醇雾化吸入对毛细支气管炎患儿炎症应激反应的影响

摘要

目的:探讨高渗盐水+沙丁胺醇雾化吸入对毛细支气管炎患儿炎症应激反应的影响.方法:选择在本院接受治疗的毛细支气管炎患儿92例,随机分为对照组及研究组各46例.对照组接受生理盐水+沙丁胺醇雾化吸入治疗,研究组接受高渗盐水+沙丁胺醇雾化吸入治疗.对比两组不同时间点血清中炎症介质、氧化应激指标含量的差异.结果:T0时,两组血清中炎症介质及氧化应激指标含量的差异无统计学意义.T1、T2时,研究组血清中炎症介质IL-4、IL-6、IL-8、hs-CRP的含量低于对照组;血清中氧化应激指标AOPPs、LHP、MDA的含量低于对照组,CAT、SOD的含量高于对照组.结论:毛细支气管炎患儿接受高渗盐水+沙丁胺醇雾化吸入治疗,可更为有效的抑制患儿全身炎症及氧化应激反应,减轻病情.%Objective:To investigate the effect of inhalation of hypertonic saline and salbutamol aerosol inhalation on in-flammatory stress response in children with bronchiolitis.Methods:92 children with bronchiolitis treated in the hospital be-tween April 2015 and May 2017 were divided into control group(n=46)and study group(n=46)by random number table. Control group were treated with saline + salbutamol aerosol inhalation,and study group were treated with hypertonic saline +salbutamol aerosol inhalation.The differences in serum contents of inflammatory mediators and oxidative stress indexes were compared between the two groups at different points in time.Results:There was no statistically significant difference in the se-rum contents of inflammatory mediators and oxidative stress indexes between the two groups at T 0.At T1 and T2,serum in-flammatory mediators IL-4,IL-6,IL-8 and hs-CRP contents of study group were lower than those of control group;serum ox-idative stress indexes AOPPs,LHP and MDA contents were lower than those of control group whereas CAT and SOD contents were higher than those of control group.Conclusion:Hypertonic saline + salbutamol aerosol inhalation can be more effective in inhibiting systemic inflammatory response and oxidative stress response and relieving the illness in children with bronchiolitis.