Clinical effect of microecological preparation combined with bicyclol on non-alcoholic fatty liver and its effect on liver fibrosis, blood lipid levels, serum inflammatory factors and TGF-β1

摘要

Objective:To investigate the clinical effect of microecological preparation combined with bicyclol on nonalcoholic fatty liver (NAFLD) and its effect on liver fibrosis, serum inflammatory factors and transforming growth factorβ1 (TGF-β1).Methods:106 patients with NAFLD were randomly divided into control group (53 cases) and case group (53 cases). The control group was given routine liver protection and bicyclol, and the case group was given Bifidobacterium triple viable probiotics based on the treatment of the control group. The two groups were treated for 6 weeks. The clinical effect, liver fibrosis, serum inflammatory factors, TGF-β1 and other changes were observed in the two groups after treatment.Results:The total effective rate of the case group was significantly higher than that of the control group (96.22% vs 83.02%), (χ2=4.970,P=0.026). After treatment, the ALB and HDL levels of the two groups of patients were higher than before. ALT, AST, and TBIL, LN, HA, PCIII, CIV, TC, TG, LDL, IL-6, TNF-a, hs-CRP, TGF-β1 were lower, compared with before and after treatment;and the improvement of liver function, liver fibrosis, blood lipid levels, serum inflammatory factors, and TGF-β1 in the case group was better than that in the control group, and the differences were statistically significant (P <0.05). The incidence of adverse reactions in the case group was lower than that in the control group (5.66% vs 11.32%). The difference was not statistically significant (χ2=1.093,P=0.296).Conclusion: Microecological preparations combined with bicyclol in the treatment of NAFLD have exact clinical effects, can significantly improve liver function, regulate blood lipid levels, reduce inflammation and liver fibrosis, and have good safety, which deserves further clinical research and promotion.