Efficacy of corticosteroids injection and autologous bone marrow injection in the treatment of simple bone cyst in children: a meta-analysis

摘要

Objective: Evaluating the effectiveness of steroids and autologous bone marrow injection in the treatment of children with simple bone cysts. Methods: The literatures of Pubmed, CBM, CNKI, Wanfang Data, and VIP Database were compared in the database of corticosteroids injection and autologous bone marrow injection for the treatment of children with simple bone cysts. The literature was retrieved until June 2018. Read the abstract or full text of the literature carefully, track the references, evaluate the quality of the included literature and extract the data, and use Rev Man 5.3 for Meta-analysis. Results: There were five studies were included, a total of 246 children with simple bone cysts were enrolled in the study. Of these, 132 received percutaneous steroid injection and 114 received percutaneous autologous bone marrow injection. Comparison of percutaneous steroids injection with autologous bone marrow injection, there was no significant difference in overall cure rate (OR = 1.29, 95％, CI = 0.57～2.88, P = 0.54), incidence of pathological fractures after surgery (OR = 1.04, 95％, CI = 0.47～2.30, P = 0.92), and recurrence rate (OR = 3.24, 95％, CI = 0.96～10.96, P =0.06). Conclusion: There was no significant difference in the efficacy of percutaneous steroid injection and autologous bone marrow injection in the treatment of children simple bone cyst.