Effect of laparoscopic radical resection of colon cancer on immune function, stress response and gastrointestinal hormones in patients with colon cancer

摘要

Objective:To investigate the effect of laparoscopic radical resection of colon cancer on immune function, stress response and gastrointestinal hormones in patients with colon cancer. Method:140 patients with colon cancer admitted to a hospital from January 2016 to November 2017 were divided into control group and observation group according to the operation method, 70 cases in each group. The control group was treated with open radical resection of colon cancer, while the observation group was treated with laparoscopic radical resection of colon cancer. The changes of immune function, stress response, visceral protein and gastrointestinal hormone were compared between the two groups before and after treatment.Results:There was no significant difference in immune function, stress response, visceral protein and gastrointestinal hormone between the two groups before operation (P>0.05). The ratio of Th1 cells was decreased, while the ratio of Th2, Th17 and Treg cells was increased in the two groups (P<0.05). The proportion of Th1 cells in the observation group was higher than that in the control group,while the ratio of Th2, Th17 and Treg cells in the observation group was lower than that of the control group (P<0.05). The levels of Cor, E and NE were increased in the two groups (P<0.05). And the levels of Cor, E and NE in the observation group were lower than those in the control group (P<0.05). The levels of PA, TRF and RBP were decreased in the two groups (P<0.05). And PA, TRF and RBP levels were higher in the observation group than in the control group (P<0.05). The GAS, MTL and GIP levels were lower in the two groups (P<0.05). And the GAS, MTL and GIP levels in the observation group were higher than those in the control group (P<0.05).Conclusion: Laparoscopic radical mastectomy has little effect on the immune function of patients. It can alleviate the surgical stress response to a certain extent, which is beneficial to the recovery of gastrointestinal function and can be extended to clinical application.