Research about the influence of different doses of urokinase on microcirculation related indicators for patients with acute myocardial infarction

摘要

Objective: To observe the influence of different doses of urokinase on microcirculation related indicators for patients with acute myocardial infarction (AMI). Methods: 240 cases of patients with AMI were randomly divided into three groups, these patients were treated with different doses of urokinase therapy, low dose group (0.5 million IU), middle dose group (1.5 million IU) and high-dose group (3 million IU). Then the differences of recanalization situation and microcirculation related indicators between the three groups were compared. Results: The recanalization rate of low dose group was lower than middle dose group and high-dose group;After 2 h of treatment, the ST segment decline, PI, AUC of low dose group were lower than middle dose group and high-dose group, QTd and enzyme-peak hours were longer than middle dose group and high-dose group, LVEF, LVESV and LVEDV were lower than middle dose group and high-dose group, all P0.05. The incidence of adverse reactions of bleeding of high-dose group was higher than middle dose group and low dose group, all P<0.05. Conclusion: 150 IU urokinase is safe, effective dose for the treatment of AMI.