Role of Notch1/2 signaling pathway in the apoptosis process of SGC-7901 induced by Oxaliplatin

摘要

Objective:To explore the role of Notch1/2 signaling pathway in the apoptosis process of SGC-7901 induced by oxaliplatin.Methods:The cell viability was detected by CCK8 and the expression of Notch1/2 and Caspase9 was detected by Western Blotting before and after treatment of oxaliplatin.Results:Oxaliplatin medication decreased the viability of SCG-7901 and increased the Notch1/2 as well as Caspase9 expression. Notch signaling pathway inhibitor L685458 normalized those abnormalities greatly.Conclusion: Oxaliplatin promotes SGC-7901 apoptosis by activating Notch signaling pathway and up-regulating Caspase9 protein.