Observation on the effect of compound indigo naturalis paster in the treatment of recurrent oral ulcer

摘要

Objective:To explore the effect of compound indigo naturalis paster in the treatment of recurrent oral ulcer (ROU).Methods: A total of 140 patients with ROU who were admitted in our hospital from May, 2015 to May, 2016 were included in the study and randomized into the observation group and the control group with 70 cases in each group. The patients in the control group were given compound indigo naturalis paster, taken after breakfast, lunch, and supper, and 60 min before sleep, continuously for 7 d, vitamin B2, 5 mg/time, 3 times/d, and vitamin C, 0.2 g/time, 3 times/d, continuously for 4 weeks. On this basis, the patients in the observation group were given Zhibo Dihuang Pill, 8 pills/time, 3 times/d, continuously for 4 weeks. The congestion area and ulcer area before treatment and 3, 7 d after treatment were detected. FCM was used to detect the peripheral blood T cell subsets (CD3+, CD4+, CD8+, and CD4+/CD8+). The full automatic biochemical analyzer was used to detect the values of IgG, IgA, and IgM.Results:With the extending of treatment time, the congestion area and ulcer area were significantly reduced when compared with the before treatment, and the reduced degree in the observation group was significantly superior to that in the control group. After treatment, CD3+, CD4+, and CD4+/CD8+ were significantly elevated, while CD8+ was significantly reduced when compared with the before treatment, and those in the observation group were significantly superior to those in the control group. After treatment, the values of IgG, IgA, and IgM were not significantly changed when compared with the before treatment, and the comparison between the two groups was not statistically significant.Conclusions:Compound indigo naturalis paster in combined with Zhibo Dihuang pill in the treatment of ROU can effectively regulate the balance state of T cell subsets, improve the immunological function, shrink the congestion area and ulcer area, and enhance the therapeutic effect; therefore, it deserves to be widely recommended in the clinic.