Study on the correlation of MMP-2 and Hyp levels in the synovial fluid with the lesion degree in patients with TMD

摘要

Objective:To explore the correlation of MMP-2 and Hyp levels in the synovial fluid with the lesion degree in patients with TMD.Methods: The clinical materials of 89 cases with TMD (97 sides) who were admitted in our hospital from December, 2010 to December, 2013 were retrospectively analyzed. According to the diagnostic results of clinical examinations and imaging examinations, 37 sides with structural disorders were served as the disorder group, 32 sides with osteoarthropathy were served as the joint disease group, and 28 sides with joint inflammation were served as the inflammation group. While 25 healthy individuals who came for physical examinations were served as the control group. The double-antibody sandwich ELISA was used to detect the levels of MMP-2 and Hyp in the synovial fluids, and their correlations with the lesion degree were analyzed.Results:The comparison of MMP-2 level among the four groups was statistically significant; the comparison between the disorder group and joint disease group was not statistically significant; the comparison between the inflammation group and other three groups was statistically significant; while MMP-2 level in the 3 groups of TMD was significantly higher than that in the control group. The comparison of Hyp level among the four groups was statistically significant; the comparison between the inflammation group and the joint disease group was statistically significant; while Hyp level in the 3 groups of TMD was significantly higher than that in the control group.Conclusions:MMP-2 and Hyp levels in the synovial fluids are different in TMD patients, are closely associated with the pathological damage, and can be served as an effective biochemical indicator in the diagnosis of lesion degree of TMD.