Effect of ropivacaine combined with dexamethasone local infiltration on the pain level and inflammatory stress response after pediatric tonsillectomy

摘要

Objective:To study the effect of ropivacaine combined with dexamethasone local infiltration on the pain level and inflammatory stress response after pediatric tonsillectomy.Methods:A total of 84 children who received selective tonsillectomy in Mianyang Central Hospital between June 2014 and April 2017 were selected as the research subjects and divided into two groups by random number table method, combined group received ropivacaine combined with dexamethasone local infiltration, and control group accepted ropivacaine local infiltration anesthesia. Serum levels of pain mediators, inflammatory mediators and stress mediators were detected 6 h, 12 h and 24 h after surgery.Results: 6 h after surgery, serumβ-EP, SP, BK, TNF-α, MCP-1, IL-4, IL-10, F-Cor, NE, AT-II and GH levels were not significantly different between the two groups; 12 h and 24 h after surgery, serumβ-EP, SP, BK levels of control group were significantly higher than those 6 h after surgery, serumβ-EP, SP, BK levels of combined group were not significantly different from those 6 h after surgery. Serum TNF-α, MCP-1, IL-4, IL-10, F-Cor, NE, AT-II and GH levels of two groups were significantly higher than those 6 h after surgery, and Serum TNF-α, MCP-1, IL-4, IL-10, F-Cor, NE, AT-II and GH levels of combined group were significantly lower than control group.Conclusion:Ropivacaine combined with dexamethasone local infiltration is with more durable and exact effect than ropivacaine local infiltration alone on relieving the pain and inflammatory stress response after pediatric tonsillectomy.