Effect of granulocyte colony-stimulating factor on the cardiac function and endothelial function in patients with myocardial infarction after PCI

摘要

Objective:To explore the effect of granulocyte colony-stimulating factor (G-CSF) on the cardiac function and endothelial function in patients with myocardial infarction after percutaneous coronary intervention (PCI).Methods: A total of 76 patients with acute myocardial infarction treated in our hospital between August 2012 and January 2016 were collected and divided into observation group and control group (n=38) according to the randomized parallel control method. Control group of patients received PCI treatment, and observation group of patients received G-CSF treatment (5 μg/kg, subcutaneous injection, 3 times/d, for 5 d) after PCI. 2 weeks after treatment, color Doppler diasonograph was used to detect cardiac function parameters, RIA method was used to detect serum cardiac function indexes, and enzyme-linked immunosorbent assay (ELISA) was used to detect serum endothelial function indexes.Results:Before treatment, differences in serum cardiac function index and endothelial function index levels were not statistically significant between two groups of patients. 2 weeks after treatment, cardiac output (CO) and stroke volume (SV) levels of observation group were significantly higher than those of control group while left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) levels were lower than those of control group; serum heart-type fatty acid-binding protein (H-FABP), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and Galectin-3 levels of observation group were lower than those of control group, endothelin-1 (ET-1) level was lower than that of control group, and nitric oxide (NO) level was higher than that of control group.Conclusion:G-CSF can enhance the cardiac function after PCI and also optimize the endothelial function in patients with myocardial infarction.