Correlation of the expression of neurotrophins family and its receptors with cell proliferation and invasion in ovarian cancer

摘要

Objective:To investigate the correlation among the expression of neurotrophins (NTs) family and its receptors with cell proliferation and invasion in ovarian cancer.Methods:Ninety patients with ovarian cancer who underwent surgical treatment in Guangyuan First People's Hospital between December 2015 and October 2017 were selected as ovarian cancer group, and 67 patients with ovarian chocolate cyst were selected as benign lesion group. The differences in the expression of NTs family and its receptors, proliferation genes and invasion genes in lesions were compared between the two groups, and Pearson test was used to further evaluate the correlation among the expression of NTs family and its receptors with cancer cell malignancy in ovarian cancer tissue.Results:NT-3 mRNA expression in ovarian cancer group was lower than that in benign lesion group whereas NT-5, TrkA, TrkB and TrkC mRNA expression were higher than those in benign lesion group; proliferation genes FUNDC1, GRP78, PTTG and SMG-1 mRNA expression were higher than those in benign lesion group whereas shSASH1 and ESRP1 mRNA expression were lower than those in benign lesion group; invasion genes Clusterin, EFEMP1, Twist and IFITM1 mRNA expression were higher than those in benign lesion group whereas DUSP10 mRNA expression was lower than that in benign lesion group. Pearson test showed that the NT-5, TrkA, TrkB AND TrkC mRNA expression in ovarian cancer were directly correlated with cancer cell proliferation and invasion activity.Conclusion: The expression levels of NTs family and its receptors are abnormal in ovarian cancer and the specific expression levels are directly correlated with the proliferation and invasion activity of cancer cells.