多孔球形羟基磷灰石的制备及其药物控释性能的研究

摘要

研究了多孔球形羟基磷灰石生物材料的制备及其对药物的控释性能。采用微乳液法先制得多孔球形碳酸钙,并以此为模板与磷酸氢二钠在一定条件下反应制备出多孔球形羟基磷灰石,通过X射线衍射,扫描电子显微镜等手段对制备的羟基磷灰石的组成和形貌进行了表征,并以硫酸庆大霉素为模型药物,研究了多孔球形羟基磷灰石对庆大霉素的体外释放规律。结果表明制备的多孔球形羟基磷灰石直径约10μm,粒度均匀,分散良好,且对庆大霉素的载药率为18.0%,包封率为46.0%,持续释药时间达到10d。多孔球形羟基磷灰石作为药物载体材料对药物具有很好的缓释作用。%Preparation of porous spherical hydroxyapatite（HAP） and in vitro releasing were investigated in this paper.Porous spherical HAP biomaterials were successfully synthesized by a microemulsion reaction using porous spherical CaCO3 and Na2HPO4 as reactants.The obtained HAP was characterized by scanning electron microscopy（SEM）,and X-ray diffraction（XRD）.The drug release property of HAP in vitro was also investigated using gentamicin sulfate as a model drug.The results show that porous spherical HAP particles with uniform particle size of about 10μm were well dispersed and its entrapment efficiency and loading efficiency were 46.0% and l8.0% respectively.The gentamicin sulfate in HAP was released about 10 days.Porous spherical HAP had favorable drug release behavior in vitro as drug delivery vehicles.