医用316L不锈钢表面微结构的飞秒激光制备及血液相容性研究

摘要

Microstructures with a good blood compatibility on the surface of stainless steel were prepared by using a femtosecond laser.The mechanism of the blood compatibility improvement was analyzed from the wet-tability of the microstructure perspective.With laser fluence increasing,we fabricated single typical laser-in-duced periodic surface structures (LIPSS)on the submicron scale and double-scale structure:periodic ripples and periodic cone-shaped spikes on the micron scale,both covered with LIPSS.After silanized,the apparent contact angles of these microstructures become larger than 150°,which meets the superhydrophobic perform-ance requirements.With the laser fluence increasing,the apparent contact angles increase,and especially the contact angle of the cone-shaped double-scale structure reaches as high as 163.8°.The blood compatibility of the microstructures was evaluated with 3 conventional evaluation methods.The results show that the blood com-patibility of the microstructures was significantly better than that of the polished surface,and that with the con-tact angles of the surface increasing,the blood compatibility can be further improved.%利用飞秒激光在316L不锈钢表面诱导制备血液相容性微结构，并从微结构的润湿性角度分析血液相容性改善的机理。随着激光能量密度的增加，在样品表面分别制备了单一的亚微米级典型激光诱导周期性波纹(LIPSS)，以及两种双尺度结构，即覆盖了LIPSS的微米级波纹结构和锥状钉结构。硅烷化后的微结构样品表观接触角都超过150°，达到了超疏水性能要求，并且随着所采用激光能量密度的增强而增大，尤其是锥状钉双尺度结构的接触角达到了163.8°。采用了3种常规评价方法对微结构表面的血液相容性进行了评价，结果表明微结构表面的血液相容性显著优于光滑表面，且随着表面的表观接触角的增大而改善。