盐酸阿霉素在纳米载体氧化石墨烯上的可控负载与释放

摘要

采用改性Hummers法制备了氧化石墨烯,并探索了其在生物医学方面作为纳米药物载体的应用.通过超声、振荡等方法制备了氧化石墨烯盐酸阿霉素(GO-DXR),采用高分辨透射电镜(HRTEM)、傅里叶变换红外光谱(FT-IR)、紫外-可见分光光谱(UVVis)等测试方法对GO负载DXR前后的形貌和结构进行了研究.DXR在GO上的负载量高达4.6mg/mg,DXR的释放量可通过pH值控制,说明GO与DXR之间依靠氢键作用结合.%We synthesize nano-graphene oxide with modified hummers and explore the biological applications of nano-graphene oxide as a nanocarrier. A novel graphene oxide-doxorubicin hydrochloride was prepared via a method of sonication and oscillation, the loading and release behaviors of DXR on GO were investigated by high-resolution transmission electron microscopy (HRTEM), Fourier transform infrared spectroscopy and UV-Vis spectrophotometer. The loading capacity was up to 4. 6mg/mg, the release of DXR indicated strong pH depend-ence and imply hydrogen-bonding interaction between GO and DXR.