血清网膜素-1与前列腺癌的相关性研究

摘要

目的：研究血清脂肪因子网膜素-1(omentin-1)与前列腺癌的相关性.方法2015年7月至2016年3月我科收治的前列腺癌患者44例作为肿瘤组,同期前列腺增生患者42例作为对照组,两组患者的年龄相匹配,均空腹经肘静脉采集血液,ELISA 法测定血清 omentin-1水平.结果与对照组相比,肿瘤组患者 omentin-1、PSA、高密度脂蛋白胆固醇(HDL-C)水平明显升高,差异有统计学意义(P ＜0．05).各项参数的 Spearman 相关性分析显示 omentin-1与 HDL-C、PSA水平呈正相关(分别 r ＝0．363,P ＝0．0006；r ＝0．356,P ＝0．0008),与空腹血糖水平呈负相关(r ＝－0．230,P ＝0．033).二项 Logistic 回归分析显示 omentin-1水平的独立影响因素是肿瘤分组,即罹患前列腺癌是使患者血清 omentin-1水平升高的一个独立影响因素(P ＝0．0004).结论血清脂肪因子 omentin-1水平在前列腺癌与前列腺增生患者间有显著差异,提示其可能与前列腺癌的发生发展相关.%Objective To evaluate the correlation between serum adipocytokine omentin-1 lev-els and prostate cancer (PCa). Methods Forty-four patients who had been histopathologically di-agnosed with PCa at department of Urology,the first affiliated hospital of Anhui Medical University were included as experimental group,while forty-two controls with benign prostatic hyperplasia (BPH)were enrolled in the study from July 201 5 to March 201 6.Among them,age was matched in two paired groups.Venous blood was obtained from all patients and healthy people in a fasting state. The omentin-1 levels were determined via utilizing enzyme-linked immunosorbent assays (ELISA)in the paired groups. Results As a result,the levels of serum omentin-1,prostate specific antigen (PSA)and high density lipoprotein cholesterol (HDL-C)were higher compared with the control group,with statistically significant differences (P < 0.05 ).Using the non-parametric Spearman’s rank correlation analysis,we found that serum omentin-1 levels were positively correlated with HDL-C,PSA (r = 0.363,P = 0.000 6;r = 0.356,P = 0.000 8 ).Meanwhile,negative association was found between serum omentin-1 levels and fasting blood glucose (FBG)(r = -0.230,P =0.033). Additionally,binary logistic regression analysis indicated that the serum omentin-1 levels might be the independently influential factor for PCa. Conclusions Serum circulating levels of adipocytokine omentin-1 were significantly different in PCa group and BPH group,suggesting the tight association between omentin-1 and PCa initiation or progression.