奥沙利铂联合方案化疗对TNM Ⅲ期结肠癌患者免疫功能及VEGF、p53表达的影响

摘要

Objective To discuss the effect of FOLFOX on immunologic function and the expression of VEGF and p53 in advanced colorectal cancer after surgery.Methods 90 patients with stage Ⅲ colorectal cancer admitted to our hospital from Jan 2010 to Dec 2015 were randomly assigned to the treatment group and control group,with 45 cases in each group.The curative effect,immunologic function and the expression of VEGF and p53 were compared between the two groups.Results The curative effect in the treatment group was significant better than in the control group.There were significant differences in local recurrence rate,metastasis rate and tumor-free survival rate between the two groups (P＜0.05).The levels of IL-2,IFN-γ and TNF-α in the two groups were similar (P ＞0.05).After chemotherapy,the levels of IL-2,TNF-α and IFN-γdecreased significantly (P＜ 0.05) and were higher in the observation group than that in the control group (P＜ 0.05).There was no significant difference in IL-6,IL-10 and IL-4 between the two groups before chemotherapy (P ＞ 0.05).After chemotherapy,the levels of IL-6,IL-10 and IL-4 in the two groups were significantly higher than those before chemotherapy (P＜ 0.05) and were significantly lower in the treatment group than that in the control group (P＜ 0.05).There was no significant difference in VEGF and p53 expression between the two groups (P ＞ 0.05).After chemotherapy,the expression of VEGF and p53 in the two groups decreased significantly and were significantly lower in the treatment group than those in the control group (P＜ 0.05).Conclusion Postoperative Oxaliplatin chemotherapy has favorable effect for patients with advanced colorectal cancer.It stabilizes the immune function and lowers the level of expression of VEGF and p53.%目的 探究奥沙利铂联合方案化疗对TNMⅢ期结肠癌患者免疫功能及VEGF、p53表达的影响.方法 选取2010年1月至2015年12月泰州市第二人民医院普外科收治的90例Ⅲ期结肠癌患者为研究对象,随机将患者分为对照组和观察组(每组各45例),对照组接受氟尿嘧啶+亚叶酸钙治疗,观察组在对照组的基础上联用奥沙利铂.比较两组免疫功能指标及VEGF、p53表达水平,以及术后2年复发、转移及无瘤生存率.结果 术后随访2年,两组局部复发率、转移率以及无瘤生存率差异均有统计学意义(P＜0.05).化疗前,两组IL-2、IFN-γ、TNF-α差异均无统计学意义(P＞0.05);化疗后,两组IL-2、TNF-α及观察组IFN-γ水平均较化疗前显著升高,观察组上述指标水平均显著高于对照组(P＜0.05).化疗前,两组IL-6、IL-10、IL-4差异均无统计学意义(P＞0.05);化疗后,两组IL-6、IL-10、IL-4水平均较化疗前显著降低,观察组上述指标水平均显著低于对照组(均P＜0.05).两组化疗前VEGF、p53表达水平差异均无统计学意义(P＞0.05);化疗后,两组VEGF及p53表达水平均显著低于化疗前,观察组上述指标水平显著低于对照组(P＜0.05).结论 术后奥沙利铂联合方案化疗对Ⅲ期结肠癌患者治疗效果较好,利于免疫功能稳定、降低VEGF及p53的表达水平.