Objective To investigate the characteristics and clinical significance of serum lipid metabolism in patients with colorectal cancer.Methods 669 cases of colorectal cancer who received surgical therapy at Department of Colon,Rectum & Anus Surgery,the first affiliated hospital of Guangxi Medical University from September 2012 to September 2014 were recruited.Total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),apolipoprotein A Ⅰ (apoA Ⅰ),apolipoprotein B (apoB) and lipoprotein a (Lpa) were measured.The relationships between clinicopathological findings and preoperative blood lipid level were analyzed.Results Lipid profile had no correlation with age,nerve invasion,vessel invasion and histology type.TC,apoA Ⅰ and HDL-C were markedly higher in female patients with CRC than that in male patients (P < 0.05).TC,apoB,apoA Ⅰ,LDL-C and HDL-C in patients with colon cancer were significantly lower than those with rectum cancer (P < 0.05).TC,apoA Ⅰ and HDL-C had significant correlation with infiltration.There was also significant correlation between apoA Ⅰ,Lpa,HDL-C and TNM staging.Lipid profile had no significant correlation with prognosis (all P > 0.05).Conclusion The level of blood lipid metabolism was related to the clinicopathological progress of colorectal cancer,but these lipid parameters had no significant correlation with prognosis.%目的 探讨结直肠癌患者血脂代谢水平的特征和临床意义.方法 以2012年9月至2014年9月在广西医科大学第一附属医院结直肠肛门外科住院手术治疗的669例结直肠癌患者为例,检测血总胆固醇(TC)、甘油三酯(TG)、载脂蛋白AⅠ(apo AⅠ)、载脂蛋白B(apoB)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)和脂蛋白a(Lpa)水平,分析临床病理资料和术前血脂检测值的关系.结果 术前血脂各指标水平与年龄、神经浸润、脉管浸润和组织学类型无关.女性结直肠癌患者的TC、apo A Ⅰ和HDL-C显著高于男性患者(均P<0.05).结肠癌患者的TC、apo A Ⅰ、apoB、LDL-C和HDL-C水平显著低于直肠癌患者(均P< 0.05).TC、apo A Ⅰ和HDL-C与肿瘤浸润层次有关(均P<0.05).apo A Ⅰ、Lpa和HDL-C与结直肠癌TNM分期有关(均P< 0.05).术前血脂各个指标与结直肠癌术后生存期无关(均P>0.05).结论 血脂代谢水平与结直肠癌临床病理进展有关,但与预后无关.
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