七氟醚及丙泊酚对老年结肠癌根治术患者血液流变学及凝血功能的影响

摘要

目的 探讨分析七氟醚与丙泊酚对老年结肠癌根治术患者血液流变学及凝血功能的影响.方法 纳入本院2014年1月至2016年12月204例老年结肠癌根治术患者为研究对象,随机均分为两组,P组应用以丙泊酚为主的麻醉方案,S组应用以七氟醚为主的麻醉方案.对比两组手术时间、术中失血量、总住院时间,并分别于术前、术后30 min检测血液流变学指标及凝血功能指标.结果 两组手术时间、术中失血量、总住院时间均无明显差异(均P＞ 0.05),两组术后中切及低切全血黏度均明显下降(均P＜ 0.05),凝血酶时间及凝血酶原时间均明显上升(均P＜0.05),但均未见对血液流变学及凝血功能产生严重影响.两组手术前后组间对比,高切、中切及低切全血黏度,纤维蛋白原、凝血酶时间及凝血酶原时间均无明显差异(均P＞ 0.05).结论 七氟醚与丙泊酚用于老年结肠癌手术,均未见严重影响患者血液流变学及凝血功能,安全性良好.%Objective To compare the effect of sevoflurane and propofol on haemorheology and coagulation in older patients with colon cancer undergoing radical resection.Methods This was a randomized controlled trial.204 older patients with colon cancer undergoing radical resection in our hospital from January 2014 to December 2016 were randomly assigned into two groups.Group P received propofol-based anesthesia,and Group S sevoflurane-based anesthesia.The operation duration,blood loss,total hospitalization duration were compared between the two groups.Haemorheology indices and coagulation indices were evaluated before and 30min after operation.Results There were no significant differences in the operation duration,blood loss and total hospitalization duration between the two groups (P ＞ 0.05).In both groups,the whole blood middle-and low-shear viscosity decreased significantly (P ＜ 0.05),thrombin time and prothrombin time increased significantly after operation (P ＜ 0.05),but blood rheology and coagulation function were not seriously affected.Before and after operation,whole blood high-,middle-and low-shear viscosity,fibrinogen,thrombin time and prothrombin time were similar between the two groups (P ＞ 0.05).Conclusion Neither Sevoflurane nor propofol would not affect the haemorheology and coagulation in older patients with colon cancer.They both have good safety profile.