乳腺癌保乳治疗十年随访

摘要

目的 研究乳腺癌保乳治疗的远期疗效及规范化治疗.方法 对1990年3月至2010年3月行保乳治疗的93例乳腺癌进行回顾性分析.结果 经过125个月的中位随访期,局部复发率3.2%(3/93),总生存率89.2%(83/93),美容效果满意率90.3%(84/93).5年生存率92.3%,无瘤生存率为89.2%;10年生存率89.3%,无瘤生存率为85.7%.在预后相关指标单因素分析中,未能发现年龄、肿瘤大小、临床分期、腋淋巴结转移等因素对预后产生影响.结论 早期乳腺癌行保乳治疗,原发肿瘤较大甚至临床分期较晚的乳腺癌经新辅助化疗缩小病灶后行保乳治疗,局部复发率较低,生存率较高,并且明显改善了患者的生活质量.%Objective To study the long - term outcomes of breast cancer undergoing breast -conserving therapy and find a standardized protocol. Methods Ninety - three cases of breast cancer undergoing breast - conserving therapy were retrospectively reviewed March 1990 to March 2010. Results During a median follow- up period of 125 months,the local recurrence rate was 3.2％ ;The total survival rate was 89.2％ ,and the cosmetic satisfaction rate was 90.3％. The 5 - year survival rate was 92.3％ ,and the disease - free survival was 89.2％. The 10 - year survival rate was 89.3％ ,and the disease - free survival was 85.7％. Single - indictor analysis revealed that age, tumor size, TNM stage and axiilary lymph node metastases had no influence on prognosis. Conclusion The patients with breast cancer, including early breast cancer, breast cancer with large tumor size and breast cancer with late TN M classification, who undergo breast - conserving therapy after receiving neoadjuvant chemotherapy, have low local recurrence rate, high survival rate and good life quality.