高效抗逆转录病毒治疗联合化疗对HIV感染合并肺癌患者的CD4+计数和生存质量评分的影响

摘要

Objective To explore the Effect of highly effective anti-retroviral therapy combined with chemo-therapy on CD4+ counts and quality of life scores in patients with HIV infection and lung cancer. Methods The re-searchers screened 48 patients with AIDS/HIV infection complicated with lung cancer from Jan 2011 to Aug 2014 in Shanghai public health clinical center. The subjects were divided into two groups, the HAART ( n =24 ) therapy combined with chemotherapy group and the chemotherapy group (n=24). Their general information, clinical mani-festations, pathological examination and immune level, CD4+T lymphocyte count, and Karnofsky score were analyzed. The correlation between the KPS and CD4+T scores of patients in each group were counted after treatment. Results After treatment, CD4+T count and KPS score were significantly higher in the combined group than in the chemotherapy group (P<0. 05). The level of KPS and CD4+T score in each group showed a high degree of consistency, and the re-lationship was positive correlation (P<0. 05). Conclusion For patients with advanced lung cancer, chemotherapy combined with HARRT treatment can improve their immunity and quality of life.%目的：探究高效抗逆转录病毒治疗联合化疗对HIV感染合并肺癌患者的CD4+计数和生存质量评分的影响。方法筛选上海市公共卫生临床中心2011年1月至2014年8月收治的AIDS/HIV感染合并肺癌的48例患者,受试者分为两组,HAART治疗联合化疗组( n=24)、单纯化疗组( n=24)。分析患者的一般资料、临床表现、病理检查及免疫水平,而且分别实施相应治疗后检测CD4+T淋巴细胞计数并进行肿瘤病人功能状态评分,并分析治疗后两组患者KPS评分与CD4+T淋巴细胞计数的相关性。结果实施相应治疗后,HAART治疗联合化疗组患者的CD4+T淋巴细胞计数和KPS评分明显高于单纯化疗组的患者( P<0．05)。治疗后两组患者KPS评分与CD4+T淋巴细胞计数的检测水平间呈现出高度的一致性,呈正相关关系( P<0．05)。结论对于晚期肺癌患者实施化疗联合HARRT治疗可以提高患者的免疫能力和生活质量。