男性慢性精神分裂症患者血清脑源性神经营养因子和胶质源性神经营养因子水平及认知功能的对照研究

摘要

Objective:To investigate the level of serum brain-derived neurotrophic factor(BDNF),glial cell line-derived neurotrophic ( GDNF ) , neurocognitive function and their relevance in patients with chronic schizophrenia. Method:39 patients with chronic schizophrenia and 57 normal controls were recruited. Posi-tive and negative symptom scale( PANSS) was used to evaluate the symptoms of patients. Serum BDNF and GD-NF protein levels were detected with ELISA. And neurocognitive function was evaluated by digital cancellation test,trail taking test( TMT) ,WMS-III spatial span test( WMS-III SST) ,paced auditory serial addition test( PA-SAT) ,stroop test and block design. Results:The serum BDNF level in patients was lower than that in control group,and the difference was statistically significant(t=9. 112,P<0. 01);But there was no significant differ-ence in serum GDNF level between patients and control group(t=1. 513,P>0. 05). Compared with the control group,the performance of patients in digital cancellation test, TMT-A, TMT-B, Stroop Test, block design, the WMS-III SST retrograde and PASAT was poor(P<0. 05). The serum BDNF level of patients was negatively cor-related with scores for positive symptoms and number of errors in digital cancellation test( r=-0. 295,P=0. 026;r=-0. 262,P=0. 049). And serum GDNF level was positively correlated with scores for color word inter-ference test of stroop(r=0. 263,P=0. 048). Conclusion:Chronic stable patients with schizophrenia still have extensive neurocognitive impairment. BDNF may be a kind of quality marker of schizophrenia,which may be in-volved in the patient's attention disorder.%目的：：探讨慢性精神分裂症患者血清脑源性神经营养因子( BDNF)、胶质源性神经营养因子水平( GDNF)和神经认知功能的变化及它们之间关系。方法：入组慢性精神分裂症患者57例和正常对照39名。采用阳性与阴性症状量表( PANSS)评估患者的精神症状。使用酶联免疫吸附法检测血清BDNF、GDNF蛋白水平,采用数字划消测验、连线测验( TMT)、WMS-III空间广度测验( WMS-III SST)、定步调连续加法任务测验( PASAT)、Stroop测验、木块图评估神经认知功能。结果：患者组血清BDNF水平低于对照组,差异有统计学意义(t=9.112,P<0.01),患者组血清GDNF与对照组相比差异无统计学意义(t=1.513,P>0.05)。患者组数字划消测验、TMT-A、TMT-B、Stroop测验、木块图、WMS-III SST逆行分、PASAT成绩均差于对照组(P<0.05)。患者组血清BDNF水平与PANSS阳性症状分、数字划消测验中的错误个数呈负相关(分别为 r=-0.295,P=0.026；r=-0.262,P=0.049),血清 GDNF水平与Stroop色词干扰测验分呈正相关(r=0.263,P=0.048)。结论：慢性稳定期的精神分裂症患者仍存在广泛的神经认知损害。 BDNF可能是精神分裂症的一种素质性标记,可能参与了患者的注意障碍。