血清葡萄糖-6磷酸异构酶测定在幼年特发性关节炎中的临床意义

摘要

Objectives To investigate whether the serum levels of Glucose-6-Phosphate Isomerase ( G6PI ) can be used as a diagnostic marker or indicator of disease activity for juvenile idiopathic arthritis (JIA). Methods A total of 86 children were enrolled in this study, and were divided into JIA group ( n = 30 , healthy group ( n = 37 ), and systemic lupus erythematosus (SLE) group (n = 19 ). The serum G6PI levels were measured by enzyme-linked immunosorbent assay. Results The mean serum G6PI levels were 0.15 ± 0.11 μg/ml in the JIA group, 0.17 ± 0.28 μg/ml in the healthy group, and 0.22 ± 0.41 μg/ml in the SLE group. There were no statistical differences between all groups ( all P ＞ 0.05 ). The cases with high G6PI in each group were the same. Conclusions Serum G6PI levels cannot be used clinically as a diagnostic marker for JIA.%目的 了解血清葡萄糖-6磷酸异构酶(G6PI)在多关节型和少关节型幼年特发性关节炎(polyarthritis and oligoarthritis JIA,pJIA and oJIA)及系统性红斑狼疮(SLE)患儿中的表达水平,以阐明其对pJIA和oJIA的诊断价值.方法 JIA组30例、SLE组19例和健康组37名.应用酶联免疫吸附试验(ELISA)测定三组儿童血清G6PI浓度,比较三组血清G6PI浓度、G6PI阳性率.结果 JIA组血清G6PI浓度为(0.15±0.11)μg/ml,SLE正组为(0.22±0.41)μg/ml,健康对照组为(0.17±0.28)μg/ml,三组比较差异无统计学意义(P＞0.05).各组G6PI高浓度例数均为2例,各组间相比差异无统计学意义(P＞0.05).结论 血清G6PI浓度测定不适用于辅助诊断关节病变为主的JIA.