Objective To evaluate the effect of continued enteral nutrition therapy in malnourished children. Methods Between 2009 and 2010 thirty malnourished inpatients, who were younger than 1 year old, were recruited. Serum albumin (ALB) , transferrin (TRF) , prealbumin (PA) , retinol-binding protein (RBP) , fibronectin (FN) , leptin (LP) , routine blood test, amino acid and anthropometric indicators were determined before and 10 days, 20 days, 30 days following the treatment of continued nasogastric feeding. Results Serum TRF, PA, RBP, FN, LP were significantly higher after 10 days treatment than before treatment (P < 0.01). Glutamine, histidine, isoleucine, alanine, valine, arginine, leucine, lysine, essential amino acids (EAA), EAAon-essential amino acids (NEAA) , branched-chain amino acids (BCAA) were higher after treatment than before treatment (P < 0.05). Tyrosine, pheny-lalanine, and total aromatic amino acids decreased significantly after the treatment (P < 0.05). Hemoglobin (HB) was significantly higher after 10 days treatment than before treatment (P < 0.05). ALB increased significantly after 30 days treatment (P < 0.05). PA, FN, LP, RBP and TRF increased gradually during the treatment (P < 0.01). Conclusions Continued nasogastric feeding can promote intestinal absorption and improve the nutritional status. TRF, PA, RBP, FN, LP and amino acids are sensitive indicators for the effectiveness of enteral nutrition.%目的 了解从儿童或成人中分离获得的金黄色葡萄球菌(金葡菌)菌株携带Panton-Valentine杀白细胞素(PVL)基因的差异.方法 分别对66株从儿童中及76株成人中分离获得的金葡菌菌株采用多重PCR,检测金葡菌16SrRNA基因、PVL基因和甲氧西林耐药决定分子A(mecA)基因;并同时检测耐甲氧西林金葡菌(MRSA)的葡萄球菌盒式染色体mec(SCCmec)基因型及亚型.结果 在66株从儿童分离的金葡菌株中,共检出7株,mecA基因阳性,MRSA 7/66(占10.6%);而在76株从成人分离的菌株中,共检出39株mecA基因阳性,MRSA 39/76(占51.3%),成人菌株MRSA发生率显著高于儿童(χ2=26.73,P<0.01).从儿童或成人中分离的金葡菌菌株PVL基因携带率分别为31/66(占47.0%)和6/76(占7.9%);从儿童或成人中分离的甲氧西林敏感金葡菌(MSSA)的PVL基因携带率分别为29/59(占49.2%)和2/37(占5.4%),儿童与成人的差异均有统计学意义(P<均0.01);从儿童中分离的2株携带PVL基因的MRSA菌株都属于SCCmecIV型,从成人中分离的4株携带PVL基因的MRSA菌株中,SCCmec Ⅰ型、Ⅱ型各1株,SCCmecⅢ型2株.结论 从儿童中分离的金葡菌株携带PVL基因阳性率较成人高,携带PVL基因以MSSA菌株为主.
展开▼
