目的：探讨高敏C-反应蛋白（hs-CRP）联合免疫功能检测在儿童肺炎支原体肺炎（MPP）中的临床意义。方法选取单纯MPP患儿103例，分为全身炎症反应综合征（SIRS）组47例和非SIRS组56例，另取26例健康儿童作为对照组，检测hs-CRP、体液免疫指标及细胞免疫指标。结果 SIRS组和非SIRS组的血清hs-CRP、IgG、IgM、CD8+水平显著高于对照组，而IgA、CD3+、CD4+、CD4+/CD8+水平显著低于对照组，差异均有统计学意义（P均<0.05）；SIRS组的hs-CRP、IgG显著高于非SIRS组，而IgA、CD3+、CD4+、CD4+/CD8+水平则显著低于非SIRS组，差异均有统计学意义（P均<0.05）；SIRS组和非SIRS组的IgM与CD8+水平的差异则无统计学意义（P>0.05）。结论 MPP患儿的体液免疫及细胞免疫功能均有紊乱，且与病情有关；hs-CRP有助于判断儿童MPP病情程度。%Objectives To detect the clinical significance of high sensitive C-reactive protein (hs-CRP) and immune function in children with Mycoplasma pneumoniae pneumonia (MPP). Methods 103 children with MPP, 47 cases of systemic inflammatory response syndrome (SIRS group), 56 cases of non-systemic inflammatory response syndrome (non-SIRS group) were recruited. 26 healthy children served as the control group. ELISA was used to detect the level of serum hs-CRP, immune in-dexes, IgG, IgA, and IgM, Cellular immune CD3+, CD4+, CD8+, CD4+/CD8+. Results The level of serum hs-CRP、IgG、IgM and CD8+in control group were significantly lower than those in non-SIRS group and SIRS group (P<0.05). The level of IgA、CD3+, CD4+, CD4+/CD8+in control group were significantly higher than those in non-SIRS group and SIRS group (P<0.05). The level of serum hs-CRP、IgG in SIRS group were significantly higher than those in non-SIRS group (P<0.05). The level of IgA、CD3+、CD4+、CD4+/CD8+in SIRS group were significantly lower than those in non-SIRS group. There was no significant difference in non-SIRS group and SIRS group of IgM and CD8+(P>0.05). The level change of serum hs-CRP were positively related with IgG (r=0.66,P=0.001) and were negatively related with IgA、CD4+、CD4+/CD8+(r=0.79, 0.67, 0.82, P all were<0.05) in chil-dren with MPP. Conclusion Children with MPP have Immunity function( including humoral immunity and cellular immunity) disorder which is related to the disease status. The level of hs-CRP could be an anpation index for the severity and immune func-tion of the children with MPP.
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