Objective To investigate the clinical characteristics of Ondine's curse syndrome secondary to multiple system atrophy ( MSA) .Methods The clinical data of 5 patients with Ondine's curse syndrome secondary to MSA admitted in our hospital from March 2009 to August 2014 were retrospecttively analyzed.Results All the 5 elderly patients developed Ondine's curse syndrome during the course of their disease,2 patients showed breathing difficulties as the first symptom and they showed apnea when sleeping.Three cases showed dizziness, ataxia or Parkinsonism as the first symptom and they had breathing difficulties at half a year,4 years and 5 years after onset.By ventilator-assisted breathing, all patients' pulmonary ventilation function were improved.Conclusion When paroxysmal short of breath occurs in elderly patients with MSA, the occurrence of Ondine's curse syndrome should be conscious.%目的 探讨多系统萎缩( MSA)合并继发性Ondine's curse综合征的临床特点. 方法 采用回顾性分析自2009年3月至2014年8月我院住院的5例MSA合并继发性Ondine's curse综合征患者的临床资料.结果 5例均为老年患者,均在病程中出现Ondine's curse综合征,2例患者以呼吸困难为首发症状;3例患者发病以头晕、共济失调、帕金森叠加综合征为首发症状,且在发病后0.5年、4年、5年时出现发作性呼吸困难症状. 经呼吸机辅助呼吸后患者通气改善. 结论 老年MSA患者出现发作性呼吸困难时,应警惕继发性Ondine's curse综合征的发生.
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