目的 探讨Th1/Th2、Tc1/Tc2细胞因子在乙型肝炎中的表达及临床意义 .方法 采用流式细胞术分析乙型肝炎患者外周血不同T淋巴细胞亚群中 细胞因子(IFN-γ、IL-4)的表达,分别比较急慢性乙型肝炎以及慢性轻、中、重度肝炎IF N-γ、IL-4表达水平的变化.结果 慢性肝炎Th2、Tc2细胞高于急性肝炎(P<0.01;P<0.05);相对于轻度组,中度Th1、Tc1以及重度组Th1、Tc1均有升高(P<0.01),相对于中度组,重度组Th1、Tc1亦有增高(P<0.05;P<0.01).结论 乙型肝炎外周血Th2、Tc2与炎症慢性化有关;随着慢性乙型肝炎活 动程度的加剧Th1、Tc1细胞逐渐增多.%Objective To explore the expressions and clinical significance of Thl/Th2 and Tcl/Ic2 cytokines in hepatitis B cases. Methods The different T cell subtypes (IFN-γ, IL-4)were assessed by flow cytometry. The levels of Th2 and Tc2 between acute and chronic hepatitis B,between slight, moderate and severe chronic hepatitis B were analyzed. Results The levels of Th2 and Tc2 were higher in chronic hepatitis B than those in acute chronic hepatitis B(P ＜ 0.01; P ＜0.05). Compared with the slight group, the levels of Thl and Tcl were higher in the moderate and severe group( P＜0.01 ). Compared with the moderate group, the levels of Thl and Tcl levels were higher in the severe group( P ＜ 0.05; P ＜ 0.01 ). Conclusions The levels of Th2 and Tc2 levels are associated with chronic inflammation in hepatitis B cases. The levels of Thl and Tcl increase with the increased inflammatory activity inhepatitis B cases.
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