全球急性冠状动脉事件注册风险评分、B型利钠肽与老年急性冠脉综合征患者冠脉病变相关性研究

摘要

目的 探讨全球急性冠状动脉事件注册(GRACE)风险评分、B型利钠肽(BNP)与老年急性冠脉综合征(ACS)患者冠脉病变严重程度的关系.方法 测定40例老年ACS患者入院24 h内血浆BNP水平,并进行GRACE风险评分,入院后1周内行冠脉造影评估冠脉病变.随访3个月,观察因心血管事件的再次住院率,分析BNP水平、GRACE评分与冠脉病变程度及再次住院率的相互关系.结果 随着GRACE评分的升高,冠状动脉病变支数及程度呈加重趋势,这与3个月内因心血管事件再次住院率增加有关.BNP水平与冠脉病变支数、程度及3个月内因心血管事件再次住院均相关.结论 GRACE风险评分和BNP均可作为老年ACS患者风险分层及短期预后的临床预测指标.%Objective To investigate the relationship between global registry of acute coronary events (GRACE) risk factors,B-type natriuretic peptide (BNP) and severe degree of coronary artery disease in senile patients with acute coronary syndrome (ACS).Methods The level of plasma BNP in 40 senile patients with ACS was detected within 24 h after hospitalization,and GRACE risk score was conducted.Coronary angiogram was applied to assess coronary artery disease within 1 week after hospitalization.Three months later,rehospitalization rate due to cardiovascular event was observed,and the mutual relationship between BNP level,GRACE score and degree of coronary artery disease and rehospitalization rate was analyzed.Results With increase of GRACE score,the branches and degree of coronary artery disease had a tendency of aggravation,which was related to increased rehospitalization rate due to cardiovascular event within 3 months.BNP level was related to both branch and degree of coronary artery disease as well as rehospitalization due to cardiovascular event within 3 months.Conclusion Both GRACE risk score and BNP can be considered as clinical predictors of risk grading and short-term prognosis for senile patients with ACS.