儿童急性肝衰竭的病因分析

摘要

儿童急性肝衰竭(PALF)是一种复杂且快速进展的综合征,病因具有年龄依赖性.分析了临床上PALF的常见病因,认为能引起PALF的病因包括:感染因素、遗传代谢性因素、中毒和药物、异常灌注和自身免疫性疾病等,其中以感染因素最常见.随着诊疗技术的提高,遗传代谢性疾病和自身免疫性疾病导致的PALF诊出率越来越高.由于PALF患儿较少,在病因诊断上尚缺乏经验,总结分析已报道的文献,以期对PALF的病因筛查提供一定的参考.%Pediatric acute liver failure (PALF) is a complex syndrome with rapid progression,and the cause of PALF is age-dependent.This article analyzes the common causes of PALF in clinical practice,including infection factors,inherited netabolic factors,poisoning and drugs,abnormal perfusion,and autoimmune diseases,among which infection factors are the most common cause.With the improvement in diagnosis and treatment techniques,the diagnostic rate of PALF caused by inherited metabolic diseases and autoimmune diseases keeps increasing.Due to the small number of PALF patients,there lacks experience in etiological diagnosis.This article summarizes related reports,in order to provide a reference for screening the causes of PALF.