目的 研究p53和survivin蛋白水平在宫内膜异位症相关性卵巢癌组织中的表达意义.方法 选取2013年2月到2015年10月期间接诊的40例子宫内膜异位症相关性卵巢癌患者作为研究组,再选取40名健康人群作为对照组.两组均进行常规检查,然后检测并记录两组患者的p53和survivin蛋白表达阳性率、卵巢癌组患者中不同病理类型p53和survivin蛋白表达PI值、不同临床分期p53和survivin蛋白表达PI值以及不同病理分级p53和survivin蛋白表达PI值并对其结果进行比较分析.结果 研究组的p53阳性率以及survivin阳性率分别为65.0%和45.0%,而对照组的p53阳性率以及survivin阳性率均为0,差异具有统计学意义(P0.05).卵巢癌组中不同临床分期以及不同病理分级的p53和survivin蛋白表达PI值均明显高于对照组患者,差异具有统计学意义(P0.05).The study group in different clinical staging and different pathological grading of p53 and survivin protein expression pI value were significantly higher than those in the control group, the difference was statistically significant (P<0.05), with the increase of clinical staging, p53 protein, and survivin table of PI value also increased gradually, and each stage p53 and survivin protein expression of PI had significant differences (P< 0.05).With the increase of pathological grade, the expression of PI and survivin protein were gradually increased, and the expression of PI and survivin protein in each grade were significantly different (P<0.05).Conclusion p53 and survivin protein expression positive rate are significantly higher in uterine endometriosis associated ovarian cancer patients.p53 protein and survivin expression of PI values are not influenced by different clinical stages and different pathological grading.
展开▼
