目的 探讨肿瘤转移相关基因-1(MTA-1)和血管内皮生长因子(VEGF)在弥漫性大B细胞淋巴瘤(DLBCL)中的表达及其与临床病理特征的关系.方法 应用免疫组织化学法检测2010年1月1日至2015年5月31日收治的43例DLBCL和20例淋巴结反应性增生患者组织中MTA-1和VEGF蛋白的表达情况.分析MTA-1和VEGF表达蛋白之间及其与DLBCL临床病理特征间的相关性.结果 MTA-1在DLBCL组织中的阳性表达率为69.8％(30/43),高于淋巴结反应性增生患者组织中35.0％(7/20),差异有统计学意义(χ2=6.808,P=0.009).VEGF在DL-BCL组织中的阳性表达率为46.5％(20/43),高于淋巴结反应性增生患者组织中20.0％(4/20),差异有统计学意义(χ2=4.069,P=0.039).DLBCL组织中MTA-1和VEGF表达水平与LDH、分期、IPI评分有关(P<0.05).DLBCL组织中MTA-1与VEGF表达水平呈正相关(r=0.411,P=0.018).结论 DLBCL组织中MTA-1和VEGF的高表达与DLBCL的发生发展有关,两者可能起协同作用.%Objective To investigate the expression and significance of metastasis associated gene - 1 (MTA - 1)and vascular endotheli-al cell growth factor (VEGF)in diffuse large B - cell lymphoma (DLBCL). Methods Immunohistochemistry was applied to detect the protein expression of MTA - 1 and VEGF in 43 cases of DLBCL and 20 cases of lymph node reactive proliferation. The correlation between MTA - 1, VEGF and the clinical pathologic factors was analyzed by chi - square test. Results The expression of MTA - 1 in DLBCL was 69. 8％ (30 / 43), much higher than that in lymph node reactive proliferation which was 35. 0％ (7 / 20),(χ2 = 6. 808,P = 0. 009). The expression of VEGF in DLBCL was 46. 5％ (20 / 43),much higher than that in lymph node reactive proliferation which was 20. 0％ (4 / 20)(χ2 = 4. 069,P = 0. 039). The expression of MTA - 1 and VEGF in DLBCL were significantly related to the levels of LDH,clinical stage and IPI score (P < 0. 05). There was a positively relationship between MTA - 1 and VEGF expression level in DLBCL (r = 0. 411,P = 0. 018). Conclusion The expressions of MTA - 1 and VEGF are highly related to the occurrence and development of DLBCL,and they may play synergetic roles in DLBCL.
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