objective:To seek a good method for plasma disinfection to solve the serious problem of viral con tamination of blood and blood products. Methods: A model of plasma disinfection was established by using ultraviolet C (UVC) irradiation and cross-linked starch iodine (CSI) treatment to kill Sindbis virus (SV). The efficacy of plasma virus inactivation was measured by assay of cell infection. The plasma IgG activity was surveyed using different immunohistochemical assays. Results: After being irradiated by 986O J/m2 UVC fol lowed by passage through a column of CSl with a velocity of 0. 25 ml/min, the SV in plasma was reduced to 6. 8 log. No significant inhibition of the activities of the antigen and antibody of IgG were found in the plas ma. Couclusion: The use of UVC in combination with CSI can effectively inactivate SV in the plasma. Thus it is a useful measure for the disinfection of blood products.
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