Objective;To study the ultrastructural changes of erythrocytes in an infant with liver-failure. Methods; Venous blood sample was collected from an infant with liver failure. Erythrocytes were observed under scanning electron microscope ( SEM ) and transmission electron microscope (TEM). Results; Under SEM, the percentage of normal biconcave erythrocytes was only 1.5% , while various abnormal erythrocytes (include elongated erythrocytes, target cells, stomatocytes, reticulocytes, acanthocytes, echinocytes and other abnormal erythrocytes) took account for a proportion of 97. 5%. Under TEM, reticulocytes and few mature erythrocytes show ropalocytosis. The club-shaped cells had branched or unbranched processes, which resulted in a maze with complex folds or deep invaginations of the cell membrane surface. Conclusions; The ultrastructure of erythrocytes was significantly altered in the infant with liver failure, suggesting that the morphosis of erythrocyte might be associated with the complexity and severity of the disease.%目的:观察肝衰竭婴儿红细胞形态的超微结构变化.方法:采集一例肝衰竭婴儿的静脉血,制作扫描电镜和透射电镜样品观察红细胞的超微结构.结果:在扫描电镜下,该婴儿正常双凹圆盘形红细胞数百分比仅为2.5％,而泪滴形、靶形、口形、网织红细胞、刺形、棘形和椭圆形等多种异常形态的红细胞却高达红细胞总数的97.5％.在透射电镜下,网织红细胞和少数成熟红细胞切面具有棒状突起,突起分枝或不分枝,甚至形成了高度曲折凹陷的迷宫图形.结论:该例肝衰竭婴儿红细胞形态从外形到内部超微结构均有显著改变,提示红细胞形态多样性可能与病情复杂和严重程度有关.
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