冠心病患者细胞因子信号转导抑制剂1基因多态性的临床意义

摘要

目的 探讨冠心病患者细胞因子信号转导抑制剂1 (SOCS1)基因多态性与心功能及细胞因子的相关性.方法 选择冠心病患者256例为研究组,健康自愿者256例为对照组.运用聚合酶链反应(PCR)及单核苷酸多态性(SNP)技术分析2组SOCS1基因多态性,并测定细胞因子和心功能的变化.结果 2组SOCS1基因rs173516427和rs15677380等位基因频率差异有统计学意义(x2=7.46、8.09,P=0.024、0.014),rs173516427 G等位基因和rs15677380 C等位基因为冠心病的高危因素(OR=1.56、1.71)；rs15677380、rs173516427不同基因型LVEF和BNP差异有统计学意义(F =10.9、12.3、9.89、11.5,P＜0.05).结论 SOCS1基因与动脉粥样硬化的发生有关,并参与冠心病的发展过程.%Objective To explore the relationship between SOCS1 gene polymorphism and heart function and cellular factors in patients with coronary heart disease.Methods A total of 256 patients with coronary heart disease were included for the study group and 256 normal people were selected as the control group.The polymorphism of SOCS1 gene were determined by polymerase chain reaction and single nucleotide polymorphism.The heart function and cellular factors were detected.Results The difference of the rs173516427 and rs15677380 allele frequencies between the study group and the control group was significantly (x2=7.46,8.09,P =0.024,0.014).The G allele of rs173516427 and C allele of the rs15677380 were risk factors to coronary heart disease (OR=1.56,1.71) ;the difference of LVEF and BNP among the rs15677380 and rs173516427 genotype was significantly (F =10.9,12.3,9.89,11.5,P ＜ 0.05).Conclusion There is an correlation between the SOCS1 gene polymorphism and carotid atherosclerosis.The SOCS1 gene participates in the development of coronary heart disease.