p-eIF4E、p-4EBP1和p-Mnk1蛋白表达在进展期鼻咽癌中的作用

摘要

目的:探讨p-eIF4E、p-4EBP1和p-Mnk1蛋白在进展鼻咽癌中的作用.方法:免疫组化SP法检测p-eIF4E、p-4EBP1和p-Mnk1蛋白在鼻咽癌组织中的表达.结果:p-eIF4E和p-4EBP1蛋白在鼻咽转移癌和复发癌中的阳性表达分别高于对应的原发癌(P=0.049,P=0.004;P=0.021,P=0.01);p-Mnk1蛋白在鼻咽原发癌和对应的转移癌、复发癌中的表达无统计学差异.结论:p-eIF4E和p-4EBP1蛋白过表达可能与鼻咽癌的发生发展及不良预后密切相关,因此,p-eIF4E和p-4EBP1蛋白有望作为鼻咽癌判断预后的较好分子标志物.%Objective:To investigate the role of expression of p-eIF4E and p-4EBP-1 and p-Mnk1 proteins in advanced Nasopharyngeal Carcinoma.Methods:The expression of p-eIF4E,p-4EBP-1 and p-Mnk1 proteins were detected in tissue array by immunohistochemistry SP method.Results:The positive expression of p-eIF4E and p-4EBP-1 proteins were significantly higher in the recurrent and metastatic tissue than corresponding primary tissue in Nasopharyngeal Carcinoma(P=0.049,P=0.004;P=0.021,P=0.01,respectively),but the positive expression of p-Mnk1 protein was no significance in recurrent and metastatic tissue and corresponding primary tissue respectively.Conclusion:The over-expression of p-eIF4E and p-4EBP-1 proteins may be closely related to the occurrence and development and adverse prognosis of NPC.Hence,p-eIF4E and p-4EBP1 proteins are expected to be better molecular markers for clinical diagnosis and prognosis of NPC.