双相(O/W)识别手性萃取苯基琥珀酸对映体的动力学研究

摘要

The determination of the intrinsic kinetics in biphasic recognition chiral extraction (BRCE) of phenylsuccinic acid (PSA) enantiomers was studied, taking the extractor! Separation of PSA enantiomers as a first order process. The BREC system was established by adding hydroxypropyl-p-cyclodextrin (HP-β-CD) in aqueous phase and L-isobutyl tartrate (L-IBTA) in organic phase as chiral selector. The different parameters affecting the extraction rate such as agitation speed, interfacial area, initial enantiomers concentration in aqueous phase, HP-β-CD and L-IBTA concentration as well as Ph in aqueous phase were separately studied. It was found that the extraction rate constant in BRCE of R-PSA and S-PSA is 32.95× 10-5 m6-mol2·s-1 and 16.18× 10-5 mol2·s-1 at 278 K, respecting. The kinetic model of this BRCE system in phenylsuccinic acid extractive separation was founded.%采用双相(O/W)识别体系对苯基琥珀酸对映体的萃取拆分过程进行动力学研究,对苯基琥珀对映体的萃取反应为一级反应；水相和有机相中使用的萃取剂分别为羟丙基-β环糊精(HP-β-CD)以及L-酒石酸异丁酯(L-IBTA);考察搅拌速度、两相接触面积、水相中苯基琥珀酸对映体浓度、水相及有机相中萃取剂浓度、水相中pH对萃取初始速率的影响.在5℃时,双相识别体系萃取分离苯基琥珀酸的S-、R-型对映体的萃取速率常数分别为32.95×10-5 m6·mol-2·s-1和16.18×10-5 m6·mol-2·s-1.建立了双相识别体系萃取拆分苯基琥珀酸对映体过程的动力学模型.