75例非小细胞肺癌患者同步放化疗致放射性肺炎的相关因素分析

摘要

目的:探讨非小细胞肺癌同步放化疗引起放射性肺炎的相关影响因素.方法:回顾性分析我中心75例非小细胞肺癌进行三维适形放疗同步化疗后出现放射性肺炎的患者的一般情况,基础肺功能及其放疗靶体积和放疗剂量的关系.结果:75例患者中肿瘤完全缓解(CR)6例,占8%;部分缓解(PR)41例,占54.67%;稳定(NC)17例,占22.67%;进展(PD)11例,占14.67%.肿瘤临床获益率为85.33%.75例肺癌患者治疗后19例出现放射性肺炎,发生率为25.3%.其中患者的一般情况包括年龄及其放疗靶体积、放疗剂量和肺V20与放射性肺炎发生相关,是本组肺癌患者放化同步治疗后放射性肺炎发生的危险因素.结论:肺部基础情况差、放疗靶体积和靶区高剂量的非小细胞肺癌患者接受同步放化疗后易发生放射性肺炎.%O b jectnve: To evaluate the correlative factors of radiation pneumonitis ( RP) induced by concurrent chemoradb-therapy fornon-small cell lung cancer( NSCLC). M e1hods: Clhical data of75 NI3CLC patients who got the RP after behg treated with3 DCRT coiibhed with concurrent chenotherapy were retrospectively analyzed Multivariate analysis was perfomed to detect the association between RP and the clhical factors Results; Of the 75 cases, 6 cases gotCR(8%), 41 PR(54.67%), 17 NC (22.67%), and 11 PD(14.67%). Clinical symptoms of RP were found hl9 cases(25.3%) of the75 patients Age of patien^ target volume of radiatbn, the radiation dose for gross tunor volume and lung20 were independently associated with RP according to the multivariate analysis C onclisim : The NSCLC patients who have poor lung conditions and have accepted high radiatbn dose for target volume and gross tun or volume combined with concurrent chemotherapy tend to getRP