唑尼沙胺与丙戊酸钠对癫痫患者认知功能的影响

摘要

目的：评价唑尼沙胺（ZNS）作为新型抗癫痫药物与传统抗癫痫药物丙戊酸钠（VPA）对癫痫患者认知功能的影响。方法唑尼沙胺与丙戊酸钠各单药治疗30例未经治疗的癫痫患者，所有患儿在治疗前、治疗后3个月及治疗后6个月时进行WAIS-CR问卷调查，对相关数据进行统计学分析。结果唑尼沙胺组患者治疗后3个月时语言能力测定分值下降，操作及总智力测定分值无明显变化；治疗6个月后语言、操作及综合智力测定分值均下降；而丙戊酸钠组患者的语言、操作及综合智测水平在治疗后3个月时、6个月时无明显变化。结论唑尼沙胺对癫痫患者的认知功能有损害作用，以语言能力的损害最为突出；丙戊酸钠对癫痫患儿的认知功能无明显影响。%ObjectiveToevaluatethecognitiveeffectsofnewantiepilepticdrugzonisamide(ZNS)and traditionalantiepilepticdrugvalproate(VPA)oncognitionimpairmentinchildrenwithepilepsy.Methods 30 untreated children with epilepsy were treated with ZNS in monotherapy; while other 30 children with epilepsy with VPA.All the patients were examined with WAIS-CR before and 3 months、6 months after the treatment .Results The children ’ s language abilities of ZNS group decreased after 3 months of treatment .The operation and total intelligence test scores showed no significant differences;The language , operaion and comprehensive intelligence test scores decreased after 6 months of treatment; while children ’ s language , operation and comprehensive intelligence testing level of VPA groups were showed no obvious changes at 3 months and 6 months of treatment .Conclusion It is suggested ZNS could damage the cognitive function of children with epilepsy , especially the language ability .The valproate could have no obvious effect on cognitive function of children with epilepsy .