TYMS gene 5'-and 3'-untranslated region polymorphisms and risk of non-syndromic cleft lip and palate in an Indian population

摘要

Dear Editor:Increased homocysteine levels due to vitamin B6 or B12 deficiency or genetic defects in folate pathway genes are associated with an increased incidence of non-syndromic cleft lip with or without cleft palate(NSCLP)^([1]).Thymidylate synthase(TS)is a folatedependent enzyme that catalyzes methylation of 2'-deoxyuridine-5'-monophosphate(dUMP)to 2'-deoxythymidine-5'-monophosphate(dTMP),a rate-limiting step in DNA synthesis,for which 5。