Objective To investe the relationship between Cornary Disease and the level of Chemerin ,and the relationship be-tween Chemmerin and Carotid Atherosclerosis .Methods Selecting 105 patients with coronary heart disease and 30 normal per-sons .All participants underwent carotid Doppler ultrasound .To measure carotid intima-media thickness (IMT) and plaque na-ture .And determination the leval of Chemerin .Compare the relationship between Chemerin level and IMT of the two groups . Results The IMT value of the Cornary group was siginificantly higher than that of normal group [(1.48 ± 0.08)mm :(1.06 ± 0.06)mm ,P<0.05] .The level of Chemerin is also have the same correlation [(232.25 ± 18.85)pg/L :(196.13 ± 10.58)pg/L , P<0.05] .However ,there was a positive correlation between the Chemerin level and IMT .Conclusions Chemerin is closely related to atherosclerosis .And it can affect the structure of carotid ,resulting in the unstable plaque .%目的：探讨Chemerin与冠心病以及Chemerin水平与颈动脉硬化的关系。方法共选入105例冠心病患者及30例正常者，对所有参与者均进行颈动脉彩色多普勒超声检查，测定颈动脉内膜中层厚度（IM T ）及斑块性质，并测定Chemerin水平，比较两组之间Chemerin水平及其与 IMT 的关系。结果冠心病组与正常对照组相比，IMT 明显升高[（1.48±0.08） mm ：（1.06±0.06）mm ，P＜0.05]，Chemerin水平[（232.25±18.85）pg/L ：（196.13±10.58）pg/L ，P＜0.05]明显升高。Chemerin水平与IM T值呈正相关关系。结论 Chemerin在动脉粥样硬化形成中具有重要作用，且可影响颈动脉结构的变化，导致斑块不稳定。
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