血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与2型糖尿病肾病的关系

摘要

Objective:To measure the serum levels of insulin-like growth factor-1 ( IGF-1 ) and insulin-like growth factor binding protein-3( IGF-BP3 ) in patients with type 2 diabetic nephropathy, and explore its correlation with type 2 diabetic nephropathy. Methods:According to the results of the urinary albumin excretion rate( UAER) ,86 patients with type 2 diabetes were divided into the simple diabetes group ( SDM group, 33 cases ) , early diabetic nephropathy group ( EDN group, 28 cases ) and clinical stage of nephropathy group(CDN group,25 cases). The levels of the IGF-1,IGF-BP3,UAER and other indicators were detected,which was used to analyze the correlations of IGF-1 and IGF-BP3 with diabetic nephropathy. Results:The serum levels of IGF-1 and IGF-BP3 and UAER in CDN group were higher than those in SDM group and CDN group(P0. 05),and was negative correlation with fasting plasma glucose(P0.05)，而与空腹血糖呈负相关关系(P<0.01)。结论：血清IGF-1、IGF-BP3水平与2型糖尿病肾病的发生发展有相关性，可作为糖尿病肾病早期的诊断指标之一。