新诊断2型糖尿病患者糖化血红蛋白与血清凝集素样氧化低密度脂蛋白受体1关系的研究

摘要

Objective:To explore the relationship between lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) and glucose level in initial diagnosis type 2 diabetes patients(T2DM). Methods:Sixty-eight initial diagnosis T2DM patients were divided into the observation group,and fifty-six non-diabetic healthy people with the same age, sex, waist circumference and BMI as the observation group were set as the control group. The levels of fasting blood glucose(FBG),glycosylated hemoglobin A1c(HbA1c),serum lipid and LOX-1 in two groups were tested. The relationship between LOX-1 and HbA1c was analyzed. Results:The levels of FBG,HbA1c,LOX-1 and LDL-cholesterol in observation group were significantly higher than those in control group(P0. 05). Multivariate linear stepwise regression analysis showed that the HbA1c level increasing was the independent risk factor of the LOX-1 level increasing(P0.05).多元线性逐步回归分析发现糖化血红蛋白的升高是LOX-1升高的独立危险因素(P<0.01).结论:血糖升高可能直接导致了LOX-1的表达上调,进而启动糖尿病患者动脉粥样硬化的进程.