精神分裂症病人维生素D缺乏与血脂异常的相关性研究

摘要

Objective:To investigate the association of vitamin D(VitD)deficiency with dyslipidemia in schizophrenic patients. Methods:Two hundred twenty-nine patients with schizophrenia were choosed,information about demographic characteristics and life style were obtained through questionnaire,and fasting blood sample was collected and plasma concentrations of 25-hydroxyvitamin D[25 (OH)D],total cholesterol (TC),triglycende(TG) and high deity lipoprotein-cholesterol(HDL-C) were measured.The association between VitD deficiency and lipid levels was assessed by χ2test and logistic regression model.Results:The mean levels of 25(OH)D, TC,TG and HDL-C in schizophrenic patients were(45.9 ± 21.3) nmol/L,(4.1 ± 0.8) mmol/L,(1.2 ± 0.7) mmol/L and(1.2 ± 0.3) mmol/L,respectively. The incidences of VitD deficiency,dyslipidemia in TC,TG and HDL-C in schizophrenic patients were 60.3%,10.9%,15.7% and 34.1%,respectively.After controlling for confounders,compared with patients without VitD deficiency, the risk of dyslipidemia in TG (adjusted OR=2.80,95% CI 1.21-6.46) and HDL-C(adjusted OR=2.48,95% CI 1.35-4.56) significantly increased in patients with VitD deficiency. Conclusions:VitD deficiency may be associated with dyslipidemia in schizophrenic patients.%目的:探讨精神分裂症病人维生素D(VitD)状态与血脂水平的关系.方法:收集229例精神分裂症病人进行问卷调查,包括一般社会人口统计学特征和近1个月生活行为方式.并抽取空腹静脉血,检测25-羟基维生素D[25(OH)D)]、总胆固醇(TC)、三酰甘油(TG)和高密度脂蛋白(HDL-C)的水平.采用χ2检验和logistic回归分析VitD与血脂异常的关系.结果:精神分裂症病人25(OH)D、TC、TG和HDL-C的平均水平分别为(45.9 ± 21.3)nmol/L、(4.1 ± 0.8)mmol/L、(1.2 ± 0.7) mmol/L和(1.2 ± 0.3)mmol/L.VitD缺乏率为60.3%.TC、TG和HDL-C异常率分别为10.9%、15.7%和34.1%.控制混杂因素后的多因素logistic回归分析显示,与VitD非缺乏组相比,VitD缺乏组TG异常风险(调整后OR=2.80,95% CI 1.21 ~6.46)和HDL-C异常风险(调整后OR=2.48,95% CI 1.35~4.56)均显著增加.结论:精神分裂症病人VitD缺乏可能与血脂代谢异常存在关联.