目的:探讨全血中性粒细胞/淋巴细胞比值(NLR)和血清胱抑素C(CysC)在2型糖尿病早期肾损害的预测价值.方法:随机选取2型糖尿病病人182例,根据尿微量白蛋白/肌酐比值(ACR)分为单纯糖尿病组(ACR0.05),而早期糖尿病肾病组年龄和全血NLR、血清CysC水平高于单纯糖尿病组(P0.05),but the age,whole blood NLR and serum level of CysC in early diabetic nephropathy group were higher than those in simple diabetic group(P< 0.05 to P<0.01).The diagnostic value of serum CysC in early diabetic nephropathy was higher than that of age and whole blood NLR.The area under ROC curve of CysC,age and whole blood NLR were 0.831,0.678 and 0.638,respectively,the sensitivities of CysC,age and whole blood NLR were 70.59%,92.86% and 92.86%, respectively,the specificities of CysC,age and whole blood NLR were 90.00%,41.27% and 36.51%,respectively,the negative predictive values of CysC,age and whole blood NLR were 84.36%,92.85% and 91.99%,respectively,and the positive predictive values of CysC,age and whole blood NLR were 80.02%,41.31% and 39.43%,respectively.Serum CysC was a risk factor in early diabetic nephropathy,and the odds ratio of which was 266.080.Conclusions:Age and whole blood NLR can be set as a screening index for early diabetic nephropathy. The serum CysC has highly predictive value,which is an independent risk factor in early diabetic nephropathy.
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