从太阳病“欲解时”与白介素含量表达探讨外感病自愈机理

摘要

Objective To investigate the self-healing mechanism of exogenous diseases based on Taiyang disease about to releasing and expression of interleukin (IL) content.Methods The mouse model was established according to the modeling method in mice with exterior syndrome of wind-cold reported by literature and experience on simulated experiment.The expression changes of serum IL content were detected by using enzyme-linked immunosorbent assay (ELISA) in model group and control group at 11∶00 and 23∶00 every day within one week.Results The expression of IL was higher in model group than that in control group at two time points (P ＜ 0.05 or P ＜ 0.01).In model group,IL content increased gradually at beginning of the disease,reached peak on the 3rd or 4th day,and reduced to the level as control group on the 7th day.Conclusion The experimental results coincide the "week thythm"of Taiyang disease about to releasing.The health qi in human body contains concept of substance and function of immune system,and IL may be an immunological material foundation of health qi.%目的 从太阳病“欲解时”与白介素含量表达探讨外感病自愈机理.方法 根据文献报道“小鼠风寒表证”模型制作方法,结合模拟实验的经验制作动物模型,采用酶联免疫吸附实验法(ELISA)定量检测模型组和对照组1周内每日11时与23时小鼠血清中白介素的含量表达变化.结果 模型组白介素的表达均高于对照组(P＜0.05或P＜0.01).模型组白介素的含量在疾病初期逐渐增高,到第3、4天达到高峰,此后逐渐回落到第7天接近对照组水平.结论 实验结果吻合了太阳病自愈的“周节律”,初步认为人体正气包含着免疫系统物质和功能的概念,白介素可能是中医正气的免疫学物质基础之一.